Microbes May Trigger or Instead Be Used To Treat Malignancies

Should antihistamines be used to treat anaphylaxis?

Unsurprisingly, a recent comparison of important international guidelines found conflicting advice about antihistamines, reflecting the uncertainty in international clinical practice: a US guideline recommends the use of diphenhydramine as second line treatment in anaphylaxis; evidence for this recommendation is graded as "expert opinion/ extrapolated from higher order evidence. DRUG INFORMATIO...

Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?

Recent epidemiological and experimental data indicate that infection with helminths can protect humans from the development of allergic disorders by immunosuppressive mechanisms that involve the induction of IL-10 and/or regulatory T cells. Furthermore, helminth-derived immune modulators suppress allergic responses in mice. Trichuris suis therapy has been shown to be safe and efficacious in tre...

To treat or not to treat: comparison of different criteria used to determine whether weight loss is to be recommended

BACKGROUND Excess body fat is a major risk factor for disease primarily due to its endocrine activity. In recent years several criteria have been introduced to evaluate this factor. Nevertheless, treatment need is currently assessed only on the basis of an individual's Body Mass Index (BMI), calculated as body weight (in kg) divided by height in m2. The aim of our study was to determine whether...

Transcatheter Arterial Chemoembolization to Treat Primary or Metastatic Liver Malignancies

Concise review: Can stem cells be used to treat or model Alzheimer's disease?

Alzheimer's disease (AD) is the leading cause of age-related dementia, affecting over 5 million people in the U.S. alone. AD patients suffer from progressive neurodegeneration that gradually impairs their memory, ability to learn, and carry out daily activities. Unfortunately, current therapies for AD are largely palliative and several promising drug candidates have failed in recent clinical tr...